ABSTRACT
To assess the role of sVCAM-1 [soluble vascular cell adhesion molecule - 1], human ANG [angiogenin] and active caspase-3 in the process of development of metastasis in female breast cancer patients and to find out the interrelations among them. Subjects and 25 female patients with early stages breast cancer [GI], 25 female patients with the late stages breast cancer [GII] and 25 apparently healthy volunteers [GIII] were studied. Plasma VCAM-1 and ANG were estimated by ELISA while PMNL [polymorphnuclear leucocyte] caspase-3 activity was estimated by colorimetric method. Plasma VCAM- 1 level was significantly increased in GI than Gill as well as between GII and GIII. As regard plasma ANG level, there was a statistically significant increase in GI than GIII as well as between GII and GIII and between GI and GII. There was a significant increase in PMNL caspase-3 activity in GII than GIII as well as in GII than GI. VCAM-1 plays an important role in breast cancer development and metastasis. ANG could be used as a tumour marker for the assessment of prognosis in breast cancer. There is an immune defects among patients with breast cancer and neutrophil apoptosis could be a feature of neoplasia and identifies a potential new target for apoptosis used therapy in breast cancer