Reaction of 1,3-dicarbonyl compounds with nitriles: synthesis of pyrazolo [1,5-c] -1,2,4-triazines, pyridines 4H-indeno [1,2-b] pyran derivatives

Several new pyrazolopyridotriazines, pyridines, 4H-pyran and H-indeno [1,2-b] pyran derivatives were prepared from beta-dicarbonyl compounds I, II and the ylidenes III and IV as starting materials

Pattern of mortality in Cairo from poisoning during the years 1976-1985

This study aimed at the investigation of deaths due to toxic agents in Cairo, during the years 1976 to 1985. Cases of food poisoning were excluded. The examid 760 cases of death due to various other toxic agents. Insecticides were responsible for 39.7% of those cases. The intake of drugs, including barbiturates and tranquillizers [minor and major], was the cause of 30.5% of the cases. Carbon monoxide caused 13.8% of the cases, while 13.0% of them were due to volatile poisons mainly alcohol [ethyl and methyl] and cyanide. The high incidence of poisoning due to insecticides calls for the necessity of studying rapid and accurate methods for their detection, particularly when the symptomatology is not conclusive, or when history of direct exposure is not available. Establishment of a poison information center and efficient laboratory services to identify poisons is mandatory

Effect of chronic maternal exposure to low carbon monoxide concentrations on the foetus

The effect of maternal exposure to low carbon monoxide concentrations, throughout gestation, was studied in 21 pregnant Buscat rabbits and was compared with seven pregnant controls. Exposure of pregnant rabbits to 100 p.p.m. CO [parts per million by volume] in atmospheric air resulted in a mean maternal carboxyhaemoglobin level of 10.6% and a mean foetal level of 15.4% compared to control values of 1.1 and 1.3% maternal and foetal carboxyhaemoglobin in non-exposed animals. A significant increase in resorption sites and intrauterine foetal deaths and a significant reduction in the litter size and in foetal birth weght was demostrated in carbon monoxide-exposed animals when compared with controls. Neuropathological changes were observed in the foetal brain in 7% of co-exposed foetuses

"Effect of organophosphorus insecticides on pregnant rabbits"

The effect of chronic maternal exposure to the organophosphorus insecticide [Tamaron, Bayer], throughout gestation, was studied in 20 pregnant Buscat rabbits and was compared with 10 pregnant controls. A significant reduction in the litter size and in the foetal birth weight was observed in Tamaron-exposed animals. In pregnant rabbits exposed to the insecticide, 10% of the mothers and 9% of their foetuses showed pathologic changes in the liver in the form of zonal necrosis, associated fatty changes and lymphocytic infiltration