ABSTRACT
The pharmacokinetic parameters and bioavailability of diltiazem following a single oral administration of a generic diltiazem 60 mg tablet [Sobhan Pharmaceuticals, Iran] were compared to those of a reference product [Entrydil, Orion Pharmaceuticals, Finland]. Twelve healthy male volunteers received a single oral dose of either formulation following overnight fasting in a double blind, randomized, crossover study. Blood samples were collected at selected times during 24 h and diltiazem plasma concentrations were determined with a sensitive HPLC method. Individual pharmacokinetic parameters, t1/2, t1/2[abs], K, Ka, Tmax, Cmax, Vd/F, Cl/F, AUC0-24 and AUC0-