ABSTRACT
The methanolic extract of Phyllanthus amarus [Fam.: Euphorbiaceae] has been phytochemically screened and tested for its analgesic activity on Swiss albino mice using Hot Plate and Tail Flick methods. The extract was investigated for its antipyretic activity by yeast induced hyperpyrexia model on male adult Wistar rats. The methanol extract reveals the presence of alkaloids, tannin and flavonoid as phytochemical constituents. The extract also produced a significant dose dependent analgesic and antipyretic activity when compared with the standard drug. Thus the present findings justified the traditional use of the plant as an analgesic and antipyretic agent
Subject(s)
Male , Female , Animals, Laboratory , Analgesics, Non-Narcotic , Plant Extracts , Methanol , Euphorbiaceae , Mice , Rats, WistarABSTRACT
Effects of ethanol and aqueous extracts of the leaves of Urtica parviflora [family Unicaceae] were studied on carbon tetrachloride induced hepatic injury in albino rats. The study revealed that both ethanol and aqueous extracts significantly reduced AST, ALT, alkaline phosphatase and total bilirubin levels. The extracts further decreased total leukocyte count. The livers of both extract treated groups showed microfatty changes with a dense collection of lymphoid cells suggesting evidence of very little necrosis or degeneration. The test extracts showed approximately normal wet weight of liver and kidneys. The present findings suggest that the leaves of Urtica parviflora possess potential hepatoprotective activity