ABSTRACT
Sixty patients were included in this study. Thirty of them were suffering from chronic sinusitis and the others were control. Serum IgA, IgM and secretory IgA were estimated using nephelometry and single radial immunodifussion techniques respectively. These immunoglobulins are responsible for the integrity of the local immune system present in the respiratory mucosa particularly the nasal mucosa. Serum Ig A and serum Ig M were significantly increased in chronic sinusitis group [P<0.05], while secretory Ig A showed an insignificant decrease in the same group [P>0.05]. Those findings indicate that activation of the mucosal immune system e .g. by nasal vaccination might be a useful and promising strategy for preventing upper respiratory infections including nasal infectious diseases