Studies on severe outbreaks of infectious bursal disease

Studies on the clinical, pathological and biochemical changes during the course of an experimental infectious bursitis in chickens were done. Clinical signs including depression, anorexia and deaths were first recorded. The bursa of fabricius were slightly enlarged on the 3rd and 4th days post infection. No precipitins against IBDV could be detected by AGPI. Infected chickens revealed a significant elevation of prothrombin time, alanine aminotransferase, creatinine and uric acid. Other parameters, like serum total proteins, alkaline phosphatase, total cholesterol and potassium levels, were declined