PMR spectrometric determination of piracetam in pharmaceutical preparations

An accurate rapid and very simple PMR method has been developed for the determination of piracetam in drug formulations. The relative st and ard deviations were 0.85%, 0.92% and 2.07% for the pure drug, the capsules and the ampoules, respectively. There was no evidence of interference from the excipients. The method was based on the comparison of the integral of the well-defined singlet at sigma 4.01 [N-CH2] of piracetam with that of the sharp singlet at sigma 6.4 [CH=CH] of maleic acid, the internal st and ard, using D2O as a solvent