Effect of some commercial antacids and tea drink on the in-vitro availability of frusemide

In this study, the dissolution rate of frusemide as a sparingly soluble diuretic, was determined in the presence of some commercial antacids. The effect of tea, as a conventional drink, on the in vitro availability of the drug in the presence of the selected antacids was also investigated. The obtained results revealed that, availability of frusemide was markedly affected in the presence of the selected antacids. The powdered antacids showed the most prominent effect, while antacid tablets produced the lowest in this respect. Also, a marked reduction in the dissolution rate of frusemide was observed in the presence of both tea and antacids. The observed reduction in the dissolution rate of frusemide with these antacids may be attributed to the chemical interaction, which was proved by IR, UV and TLC studies

Effect of some commercial antacids and tea drink on the bioavaiblilty of frusemide

The bioavailability of frusemide [FR] after oral administration of FR alone or FR with antacids or FR with antacids and tea drink was investigated using rabbits. The urinary excretion rate was monitored and drug concentrations were compared. The results revealed that the drug bioavailability was markedly reduced in the presence of the selected antacids, viz. Neogelco and Simeco suspensions, and Stomaclin powder. A significant reduction was recorded in both the total cumulative amount excreted over 24 h [P <0.05] and the excretion rate of the drug [P <0.01]. Tea drink was found to have an influence on FR absorption, if taken concurrently with the tested antacids. With Stomaclin powder, tea drink significantly [P <0.01] increased the biological availability of FR compared with that obtained with antacid alone, while such effect in case of Neogelco suspension was insignificant [P >0.05]. With Simeco suspension, however, tea drink significantly [P <0.01] reduced the biological availability of FR

Effect of drug and drink combination on the pH profile of simulated gastric juice

The pH profile of simulated gastric juice [SGJ] in presence of commercial antacids with and without frusemide [FR] and/or drink was studied. All the tested antacids elevated the pH of SGJ with different degrees. Both FR and drinks, each alone, markedly reduced the effect of some tested antacids