Diagnostic value of nucleolar organizer regions in benign and malignant epithelial ovarian tumors

Today the nucleolar organizer regions [NORS] have recently attracted much attention because of claims that frequency within the nuclei is significantly higher in malignant cells than in normal reactive or benign neoplastic cells. The present study included forty five cases. Eighteen cases were prospective and 27 were retrospective. They were grouped according to tile tumors 16 cases of mucinous tumors, 2 cases of Brenner tumors and 3 cases of endometroid carcinoma. The cases were stained by H and E and freshly prepared AgNORs solution. AgNORs appear as brown or black dots within the nucleus. There was no significant difference between benign and borderline serous tumors. But there was a significant difference between borderline and malignant serous carcinoma. Considering mucinous tumors, there was no significant difference in AgNOR count between benign and borderline mucinous tumors, however, a significant difference between benign and malignant mucinous tumors was demonstrated. Considering mucinous adenocarcinoma and endomatroid carcinomas after follow up of the cases, it was found that they had a better prognosis than those of serous adenocarcinomas. The AgNOR counts in these cases were also less than those of serous adenocarcinomas

Incidence and susceptibility to neoplasm among mice, born to neoplasm affected parents

The F1 progeny of BALB/c mice, suffering skin tumor, induced by DMBA and croton oil, showed increased incidence of skin tumors when exposed to such carcinogens. The percentages of tumors were higher in F1 generation [86 males and 98 females] than those of their parents [70 males, 90 females]. The susceptibility of F1 generation was also higher [0.94] than their parents [0.86]. These results indicated that there was an increased risk of tumor development among rodents which were born from parents suffering tumors. This could be due to the transmission of certain cancerogens from parents showing tumors to their offsprings

Health effects of automobile exhaust on garage workers

105 male workers were studied. All were comparable as regards age and socio-economic state. 42 of them were garage workers exposed to motor car exhaust gas. The rest, 63, were control group. They were all interviewed as regard the personal and occupational history. Special reference to symptoms of respiratory and urinary systems, general medical examination, and ventilatory function measurements using vicatest-4 were performed. A blood sample was obtained for laboratory tests [HB, SCOT and SGPT] and urine sample for cytological examination. It was found that there is a significantly higher rate of respiratory affection in exposed workers namely chronic bronchitis and impaired ventilatory function [FEV/VC percent <70 percent]. The percent reduction of FEV[1] and V.C. for exposed in relation to predicted values was significant. Hypertension and uninary troubles were significantly prevalent among exposed workers. No evidence of malignancy in urine cytology. However, the number of examined personal was thought to be small leading to s suggestion of screening cytology on a large scale for early detection. Also, filtering the exhaust should be done to reduce respiratory affection