Synthesis, molecular modeling and antitiumor activity of some substituted acridine derivatives

Nine series of new acridine derivatives of anticipated antineoplastic activity were synthesized. The first series consists of N,N'-1, 2-bis [9-[4-substituted sulfamoylphenyl] amino-acridine-4-carboxamide] ethylenediamine. The second comprises of N,N'-1,4-bis [9-[4- substituted sulfamoylphenyl] aminoacridine-4-carboxamide] phenylenediamine. The third and fourth are 1-[4-substituted sulfamoylphenyl] aminoacridine-4-carboxylic acid [4-substituted sulfamoylphenyl] amide. The fifth and sixth are 9-ox-1-[4-substituted amino sulfamoylphenyl]-9-10- dihydroacridine-4-carboxylic acid [4- substituted sulfamoylphenyl] amide. The seventh is 2-substituted phenyl-2,6-dihydropyrazolo [3,4,5-kl] acridine-5-carboxylic acid [4- substituted sulfamoylphenyl] amide. The eighth is 4-[5-[N'- phenylhydrazinocarbonyl-6H-pyrazolo [3,4,5-kl acridine-2-yl]-N- substituted benzene sulfonamide. The last one belongs to 2- substituted phenyl-2,6-dihydropyrazolo [3,4,5-kl] acridine-5-carboxyli acid [4-substituted sulfamoylphenyl] hydrazide

Synthesis of some new fenamic and naphthalene propionic acid esters of pharmacological activities

Three series of N-arylanthranilic and naphthalene propionic acid esters were synthesized. The first series III was prepared by incorporating an acetanilide or paracetamol moiety, whereas the second IV and third series V were prepared by forming an ester with chloroacylamino derivatives of alpha, 8-diethers of glycerol. Six compounds were tested for their analgesic, anti-inflammatory and tranquilizing activities and some of them were found to be active

Synthesis and pharmacological evaluation of some alpha, gamma-diethers of glycerol

A series of alpha, gamma-diethers of glycerol in which a ureido moiety is incorporated, so that the final new compounds may possibly posses both the tranquilizing and skeletal muscle relaxant activities, is prescribed. Some of the prepared new compounds were subjected to preliminary pharmacological screening and the results are reported

Synthesis of some alpha, gamma-diethers of glycerol of expected central nervous system depressant activity

Further study of alpha, gamma-diethers of glycerol was carried out as analogues to mephenesin. These compounds were prepared for the pharmacodynamic study of the effect of substituting the o-methyl group of mephenesin by a polar acyclic ureido group, which increased its water solubility. Some of the prepared compounds are subjected to preliminary pharmacological screening. The results are included