ABSTRACT
Nephropathy is one of the serious adverse effects in administration of contrast media in percutaneous coronary intervention [PCI]. This study was designed in order to evaluate the effect of ACEI and diuretics on contrast- induced nephropathy. This randomized clinical trial was conducted in Isfahan University of Medical Sciences in 2006. Overall, 60 persons were randomly assigned for each group. Groups A and B were treated by angiotensin converting enzyme inhibitors [ACEI] and groups C and D were treated by diuretics. In group A, ACEI was discontinued from 36 hours before PCI and in group C diuretics were discontinued as well. The post-intervention and the amount of increase in the serum creatinin [Cr] level were compared by ANOVA between groups. The increase in Cr level was not significantly different between groups A and B [0.07 +/- 0.22 vs.,0.06 +/- 0.13 mg/dL, respectively, p=0.7]. Similarly, this difference was not significant between groups C and D [0.08 +/- 0.17vs. 0.05 +/- 0.14mg/dL, respectively, p=0.2]. Regarding to non- significant difference of Cr level between the groups either continuing or discontinuing ACEI and diuretics,in the presence of normal kidney function, these drugss,have no side effect in patients undergoing PCI