effects of bromocriptine eye drops on the intraoccular pressure of patients with open angle glaucoma

The effects of three concentrations of bromocriptine eye drops on the intraocular pressure [10P] of patients with open - angle glaucoma [DAG] were investigated in a double blind, crossover and randomized study. Twenty-four patients were randomly divided into 3 groups; each of 8 patients and were given bromocriptine and placebo eye drops in a crossover design. Results showed that bromocriptine eye drops at low concentration [0.01%] significantly reduced the 10p in comparison with placebo produced no significant changes in the 10p of patients with DAG in comparison with placebo

Dopaminergic mechanism involved in the control of intraocular pressure in rabbits

Bromocriptine eyedrops specially made in a lyophyllized powder to be freshly prepared in saline, has been tested for its ocular hypotensive effects in rabbits. Bromocriptine eyedrops caused a significant reduction in the intraocular pressure [IOP] of the treated compared to that of the control eyes. Haloperidol bocked the effect of bromocriptine on the eye. However, haloperidol treatment caused a reduction in the IOP of rabbits, though this effect did not potentiate the effect of bromocriptine. These findings suggest an involvement of the dopaminergic mechanism in the control of IOP and that the ocular hypotensive effects of bromocriptine and haloperidol are mediated through an action different sites