ABSTRACT
The effect of two angiotensin converting enzyme inhibitors; namely, captopril [1.8 mg/kg/day orally] and enalapril [0.8 mg/kg/day orally] on gentamicin induced nephrotoxicity [each given seven days pretreatment for 14 days concomitantly with gentamicin] was studied in rats. Treatment with gentamicin [40 mg/kg/day IP for 14 days] resulted in an increased serum malondialdehyde and a significant decrease of urinary prostaglandin E2. It could be concluded that angiotensin converting enzyme inhibitors were of a significant value in the protection against nephrotoxic insults and they are worth to be tried clinically
Subject(s)
Drug-Related Side Effects and Adverse Reactions , Kidney , Histology , RatsABSTRACT
The aim of this study was to examine whether silymarin could protect against renal injury due to the nephrotoxic drugs as gentamicin and cisplatin. Animals were subdivided into six groups, each containing ten rats: The first group was used as a control and received normal saline orally at a dose of 0.5 ml/day for seven days, the second group was treated with silymarin orally at a dose of 200 mg/kg/day for seven days, the third group was treated with gentamicin at a dose of 80 mg/kg/day IP for seven days, the fourth group was treated with cisplatin at a single dose of 5 mg/kg IV infusion and the fifth and sixth groups were pretreated with silymarin for seven days. The present data showed clearly the protective effect of silymarin against experimentally induced nephrotoxicity