ABSTRACT
In this study, intercellular adhesion molecules [ICAM-1] and L-selectin were described in sera from 36 children suffering from idiopathic nephrotic syndrome by using ELISA. They were classified into three groups: Group I, 26 patients with minimal change nephritic syndrome [MCNS]; group II, 10 cases of non-minimal change nephrotic syndrome [MCNS] [6 cases of mesangioproliferative and 4 cases of focal segmental glomerulosclerosis] and group III,15 healthy children were enrolled to serve as controls. Patients within group I were reexamined according to the disease activity and steroid therapy. The study concluded that the elevation in serum ICAM-1 and L-selectin in MCNS and non-MCNS groups compared with the healthy controls could provide the basis for disturbance in T cell function in patients with nephrosis, suggesting that the disease is mediated by immunologic mechanisms disturbing the cellular immunity