Study of blood lipids under the effect of oral contraceptives

Serum cholesterol and beta lipoproteins were studied after the intake of Anovlar and Anovlar 1 tablets for short duration [six months] and long duration [2 to 10 years]. There was a significant increase in total serum cholesterol and in beta [atherogenic] lipoproteins, more marked in the long-term users. The state of hyperlipaemia induced by the combined pills can play a role in the pathogenesis of venous thrombosis, either by accelerating clotting or by inhibiting fibrinolysis

Study of liver function tests under the effect of oral contraceptives

A battary of liver function tests were done for a group of normal [30 cases]. Anovlar 1 tablets were given for 20 cases and the tests repeated and there was a significant increase in serum transaminases, zinc and thymol turbidity tests but no change was found in the serum alkaline phosphatase.. A group of long-term users [30 women] were also investigated for this liver functions and there wrre no significant changes in the values of these tests, this reversibility of the liver function could be explained by the phenomenon of "adaptation"

Study of the effect of oral contraceptives on blood coagulation factors

Blood coagulation factors, I, II, VII, VIII and X were assayed before and after the intake of Anovlar 1 tablets for six months and also after the long-term use of Anovlar and Anovlar 1 tables for 2 to 10 year. In both group there was a significant increase in Factors I, II, VII and X. Factors VIII [antihaemphilia globulin] showed no significant change in the studied groups

Fibrinolytic activity under the effect of oral contraceptives

Twenty women were given Anovlar 1 tablets cyclically for six months, and the fibrinolytic activity of their plasma was studied by the euglobulin clot lysis time. Pre-intake study was done for 30 women, and for another group of long-term users of Anovlar and Anovlar 1 tablets for 2-10 years. There was a significant shortening in the euglobulin lysis time in the two groups of pill users. This enhanced fibrinolytic activity counter balances the increase in the blood coagulation and thus preventing the occurrence of intravascular thrombosis