ABSTRACT
Reaction of 2-[4-[4-Chlorobenzylidene]-5-oxo-4,5 dihydroxazol2-ylmethyl]- isoindole-l,3-dione [1] with p-aminoacetophenone followed by reaction with p-chi- orobenzaldehyde afforded chalcone 3, which used was as a precursor for the synthesis of a variety of pyrazole, oxazole, pyrimidine, pyridine and oxarine compounds.On the other hand, the reaction of 1 with glycine afforded imidazolylglycine [14] which reacted with thionyl chloride followed by addition of ammonium thiocyanate to give the isothiocyanate derivative 15 which reacts with different nitrogen and carbon nucleophiles to afford new derivatives of biologically active heterocycles. The antimicrobial activities of some synthesized derivatives were examined against some selected bacteria and fungi