ABSTRACT
Background: evaluation of the diagnostic value of silver nucleolar organizer Region assessment in skin diseases is important. According to this reason, we want to study the Argyrophilic Nucleolar Organizer Region [Ag-NOR] count and Subjective Ag-NOR Pattern Assessment [SAPA] score in normal skin, Squamous Cell Carcinoma [SCC], Basal Cell Carcinoma [BCC] and Solar Keratosis [SK]
Materials and Methods: the study groups consisted of 69 cases [18 SCC, 18 SK, 17 BCC and 16 Normal skin]. The specimens were studied by microscope which were prepared by H and E staining and silver staining for Ag-NOR
Results: the mean count in SCC was 2.92, in SK 2.29 and in BCC 1.59, which was statistically significant compared to 0.93 in normal skin [p value <0.001]. The SAPA score was in SCC 7.94 in SK 7.61 in BCC 6.35 and in normal skin 5.00 [p value <0.001]
Conclusions: Ag-NOR count and SAPA score in normal and pathological status of skin has positive results