ABSTRACT
The mean concentration of manganese in the red blood cells and serum of normal healthy subjects and patients with old myocardial infarct and diabetes mellitus was determined by neutron activation analysis. The mean concentration of manganese in the red blood cells and serum of patients with old myocardial infarct (0.57+-0.45 ug/g and 0.23+-0.18 ug/g) and patients with diabetes mellitus (0.55+-0.4 ug/g and 0.24+-0.19 ug/g) were higher than normal levels of 0.11+-0.08 ug/g and 0.19 +-0.16 ug/g respectively. The importance of the investigation was discussed. (Summary)
ABSTRACT
Heart, brachial arteries and diaphragm specimens were obtained from 30 autopsy cases consisting of 18 apparently normal subjects who met accidental death and 12 patients who died of myocardial infarction were analyzed for their elemental contents by neutron activation analysis. The following trace elements were determined: Co, Cu Zn, Fe, Mn, Cr and Mo. The values of these elements in the heart tissue of normal subjects were found to be higher than those of the Swedes. The concentration of chromium among Filipinos was found to be thirty times higher than the Swedes. The importance of this finding was discussedIt is hoped that the data we obtained will add to the growing evidence that trace elements are related to diabetes and possibly to degenerative cardiovascular disease, such as hypertension, atherosclerosis and the sequela. If related, measures can be taken not only for the treatment but also for the prevention of the disease. The incidence of cardiovascular disease is increasing not only in our country but also in other parts of the world. The metals coming from the expanding environmental contamination as a result of the industrial pollution of air and water, and the use of soil fertilizers, may play a role in the increasing incidence of cardiovascular disease by producing mineral inbalance in man.(Summary)
ABSTRACT
Heart, liver and kidney specimens from 45 adult male subjects were analyzed for their zinc, copper and molybdenum contents. The normal mean values of zinc, copper and molybdenum in the heart, liver and kidney of male adult Filipinos was determined and found to be agreable with the normal mean values reported in literature. The mean concentration of zinc in the heart and liver of patients who died of myocardial infarction, 28.85+-2.07 ug/g and 37.57 +- 8.38 ug/g respectively were lower than the normal values of 30.35 +- 2.33 ug/g and 47.30 + 7.72 ug/g. The mean level of copper in patients with myocardial infarction of 3.95 +- 0.82 ug/g was lower than the normal value of 5.01 +- 1.96 ug/g. The mean concentration of molybdenum of 0.83 +- 0.13 ug/g. 0.76 + 0.36 ug/g and 0.74 +- 0.31 ug/g in the heart, liver and kidney respectively of patients with myocardial infraction were higher than the normal values of 0.32 +- 0.13 ug/g. 052 +- 0.16 ug/g and 0.41 +- 0.20 ug/gThe results and importance of our investigation was discussed. (Summary)