Synthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotoxic effect on HCC cell lines

Oleanolic acid [3p-hydroxy-olean-12-en-28-oic acid; OA-Ol], a pentacyclic triterpene, exhibit a wide range of pharmacological ad biological activities. We have isolated oleanolic acid from methanoJic extract of Periploca aphylla, collected from surroundings of Karachi in the month of February

Furthermore, four known and two new C-28 amino .Kid conjugates of oleanolic acid were prepared to explore potential of these compounds on HCCs and one breast cancer :li line. Cytotoxic effects revealed that as compare to parent compound [OA-Ol], two derivatives OA-04 [p<0.000l] and OA-06 ]p<0.0 1 ] showed significantly increased /higher inhibition rates