ABSTRACT
Background: Hyperuricemia as an independent risk factor of cardiovascular disease or not is debated for years
Objective: To determine the association of high serum uric acid level with acute coronary syndrome [ACS]
Subjects and Methods: This was a case control study, conducted from 1[st] January to 31[st] August, 2014, in Department of Cardiology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan. A total of 367 study subjects, with 193 patients taken as cases, having acute coronary syndrome [ACS], diagnosed and labeled after thorough relevant investigations and 174 controls do not having acute coronary syndrome, selected from accompanying attendants, were included in study. The variables included in study were age, sex, BMI, hypertension, smoking, serum cholesterol, HDL, LDL, triglyceride, serum uric acid level and disease status of ACS. Serum uric acid >7mg/dl in males and >6mg/dl in female was taken as high. Informed verbal consent was taken from all the cases and controls before including them in study. The data was entered and analyzed in SPSS version 16
Results: A total of 367 study subjects, with 193 patients having coronary heart disease and 174 controls do not having coronary heart disease, were included in study. The mean age of patients of ACS was 52 +/- 11 years, versus controls 47 +/- 15 years, 84% among patients of ACS versus 75% among control were male, BMI was 27 +/- 3 among patients of ACS versus 25 +/- 6 among control, HDL was 41.92 +/- 8mg/dl among patients of ACS versus 43 +/- 6mg/dl in controls, triglyceride was 172.68 +/- 98mg/dl among patients versus 168 +/- 78mg/dl in controls, LDL was 119 +/- 37mg/dl among patients versus 118 +/- 32mg/dl in controls, and serum uric acid was 6.1 +/- 1.2mg/dl among patients versus 5.1 +/- 0.3mg/dl in controls. Those who have ACS, 37.3% have high serum uric acid as compared to 24% among Non CHD subjects. [p-value 0.00]
Conclusion: This study showed that elevated serum uric acid level was statistically significantly associated with Acute Coronary Syndrome
ABSTRACT
Background: Hepatitis B virus [HBV] and Hepatitis C virus [HCV] infections are major cause of end stage liver disorders including cirrhosis and hepatocellular carcinomas. World Health Organization [WHO] has ranked Pakistan amongst the most affected and at-risk nations for HBV and HCV infections. It is therefore important to determine HBV and HCV prevalence in various communities of Pakistan
Objective: To determine HBV and HCV seropositivity in rural population of Rahim Yar Khan
Patients and Methods: A total of 1999 adults [more than 30 years of age] from rural population of Rahim Yar Khan were included in the study from August 2011 to March 2012. Individuals under study were investigated for the levels of Hepatitis B surface antigen [HBsAg] and anti HCV antibody levels using Immunochromatographic strip test [ICT strip test]. Additional information was collected in a pre-designed questionnaire that included demographic details and other factors such as occupation and level of education. Data was entered and analyzed by SPSS version 16
Results: Of the 1999 individuals investigated in this study, 53 [2.7%] individuals were positive for Hepatitis B surface antigen [HBsAg] and 476 [23.8%] were positive for anti HCV antibodies. Moreover, 13 individuals [0.7%] had co-viral infection as they were positive for both HBsAg and anti HCV antibodies. Among HBsAg positive individuals 60% were male, whereas, among Anti HCV positive individuals, 58% were females. Majority of the HBsAg and Anti HCV positive individuals were illiterate 58% and 63% respectively. 43% of the HBsAg positive individuals were self employed, whereas, 54% of the Anti HCV positive were house wives
Conclusion: This study has shown that HCV infection is more prevalent as compared to HBV in this part of the country. It is also noted that certain risk groups such as self employed individuals, housewives and those with low level of education are prone to HBV and HCV infections