ABSTRACT
Introduction: Huntington disease [HD] is a progressive neurodegenerative disease which affects movement control system of the brain. HD symptoms lead to patient's gait change and influence stride time intervals. In this study, we present a grey box mathematical model to simulate HD disorders. This model contains main physiological findings about BG
Methods: We used artificial neural networks [ANN] and predetermined data to model healthy state behavior, and then we trained patients with HD with this model. All blocks and relations between them were designed based on physiological findings
Results: According to the physiological findings, increasing or decreasing model connection weights are indicative of change in secretion of respective neurotransmitters. Our results show the simulating ability of the model in normal condition and different disease stages
Conclusion: Fine similarity between the presented model and BG physiological structure with its high ability in simulating HD disorders, introduces this model as a powerful tool to analyze HD behavior