Glucose and fluoxetine induce fine structural change in human serum albumin

Human serum albumin has been used as a model protein for protein folding and ligand binding studies over many decades. Due to its long life period and high concentration in plasma, HSA is highly sensitive to glycation. It is reported that 175 mg/dL glucose concentration is a threshold of kidney activity for the beginning of excretion of glucose. PH denaturation of HSA in absence and presence of different concentrations of glucose is studied and based on the Pace two-state model, the findings are analyzed. In addition, florescence emission data of albumin range in the period of 300-500 nm was depicted. The amounts of free energy change and [D] [1/2] parameters of unfolding in correspond to florescence date indicate that glucose induces fine structural change in human serum albumin. Results showed that 175 mg/dL glucose concentration is a critical point for albumin structural and functional alteration

Frequency of hepatitis C virus antibody in lichen planus patients admitted to dermatology ward of Sina hospital, Hamedan, Iran from 2002 to 2004

An epidemiological association of lichen planus [LP] with hepatitis C virus [HCV] infection has been found only in certain parts of the world and in some countries no association has been noted. The present study was done to evaluate the association of LP with HCV in patients admitted to Sina hospital, Hamedan, Iran from 2002 to 2004. The presence of anti HCV antibody in 32 patients with LP was compared with 43 patients suffering from other dermatoses not related to HCV. Both patient and control groups were screened for the anti HCV antibody using ELISA. The positive cases were tested again using RIBA method. Only confirmed positive cases with the RIBA method were considered as anti HCV antibody positive. Anti HCV-antibody was positive in 3.1% of patient group [one out of 32] and in 7% of control group [3 out of 43]. In Hamedan province no association was found between HCV infection and LP therefore the routine test of LP patients for anti HCV antibody is not necessary

Skin diseases in kidney transplant recipients

The aim of this study was to evaluate the frequency of skin diseases in kidney transplant recipients. This cross-sectional study was performed on 233 kidney transplant recipients in Ekbatan Hospital of Hamedan in 2004. The patients were examined by a dermatologist and diagnosis was made on the basis of clinical observations. Biopsies and scraping of the lesions were taken whenever necessary. Of the patients, 226 [97%] suffered from one or more skin lesions. The most common lesions were drug related, including hypertrichosis, gingival hyperplasia, acne, and cushingoid feature which were detected in 86.7% of the patients. Also, infectious and premalignant or malignant lesions [actinic keratosis, squamous cell carcinoma, and basal cell carcinoma] were seen in 48.9% and 14.2% of the patients. The mean duration of immunosuppressive therapy was significantly higher in patients with infectious skin diseases [P < .001]. Skin lesions are a significant problem in kidney transplant recipients. A careful monitoring of these patients is recommended in order to detect these lesions in early stages and treat them

Spectrum of skin diseases in Hamedan rural areas in 2002

Skin diseases are one of the common medical problems in population. According to dermatological journals only scant studies have estimated the prevalence of skin diseases in the general population. This study was performed to assess the prevalence of skin diseases in Hamedan rural areas in western Iran in 2002. A random cluster sampling carried out and 9450 residents in rural areas of Hamedan enrolled into the study. All participants were examined by specialist teams and skin biopsies were done when required. All examination results were recorded in relevant forms and were analysed. The most commonly observed skin diseases in study area were pityriasis alba [21%], melasma [18.5%], dermatitides [16.5%], nail disorders [13%], and acne [11.7%]. The most commonly involved anatomic areas were head and neck [66.0%], 58.3% of patients were male and the age range of all examined people was from 1 to 75 years. We found that prevalence and distribution of skin disorders in Hamedan are different from other parts of the world. Community-level education may reduce the severity and duration of these diseases resulting in a reduction of their burden of disease and public health improvement

[Anatomical location of basal cell carcinoma in relation to histopathological subtypes: analysis of 189 cases in Hamadan Sinahospital during 1997-99]

Basal cell carcinoma [BCC] is the most common skin cancer in whites. Determination of anatomical localization of BCC in relation to histological subtypes of this tumor. This survey is a descriptive cross sectional study carried out on 189 cases of BCC patients diagnosed in Hamadan Sina hospital between 1997-1999. This study showed 7 histologic subtypes of BCC. Nodular type was the most common type [55.16%] and metatypical type had the lowest frequency [3.7%]. Head and neck were the most common sites of all subtypes of this tumor and nose was the most common of involvement [22.7%]. Superficial BCC was more common on the scalp, which is due to irradiation used for the treatment of tineacapitis in the past