Formulation and in-vivo study of ketoprofen tablets prepared using chitos an interpol ymer complexes

The application of interpolymer complexes [IPCs] for oral controlled drug delivery systems was tested between chitosan and various anionic polymers viz sodium alginate, sodium carboxymethylcellulose and pectin. The prepared IPCs were investigated using Fourier transform infra-red spectroscopy and differential scanning calorimetry, Ketoprofen tablets were prepared using the polymers alone, physical mixtures of chitosan with sodium alginate, sodium carboxymethylcellulose or pectin in different ratios; 1:3, 1:1 and 3:1, and the corresponding IPCs. In-vitro release studies were carried out in two dissolution media; 0.1 N HCl ofpH 1.2 and phosphate buffer ofpH 7. 4. It was found that, chitosan - sod. carboxymethylcellulose 1PC tablets showed more controlled drug release compared to that containing chitosan - sodium alginate and chitosan -pectin IPCs. The dissolution rate from tablets prepared using physical mixtures of polymers were found to be dependant on the interaction between chitosan and each of the anionic polymers in the physical mixtures, their ratios and pH of the dissolution medium. Tablets prepared using chitosan - sod. carboxymethylcellulose physical mixture 1:1 and chitosan - sod. carboxymethylcellulose IPC were selected for the in-vivo study using albino rabbits. The results showed a lower peak plasma concentration and marked controlled release effect of drug in tablets containing the physical mixture compared to that of the IPC and the control tablets

Effect of solid dispersion techniques for surfactant incorporation on the characteristics of sulphamethoxazole suppository formulations

In vitro release, stability as well as bioavailability of sulfamethoxazole suppositories were investigated using solid techniques for surfactant incorporation. Tween 20, Tween 80 and Myrj 53 were the surfactants utilized in this investigation. Suppositories were prepared by fusion method using Witepsol H power down 15 as a base. It was found that SMZ-surfactant physical mixture showed the highest drug release form suppositories. This indicated that the technique of surfactant incorporation has a great role in enhancing the drug release from suppositories. Stability study revealed that the technique of surfactant incorporation did not affect the drug stability. Bioavailability investigation has proved that physical mixture is the technique of choice for surfactant incorporation in suppository formulations of sulfamethoxazole in fatty bases