ABSTRACT
This is a prospective study conducted on fifty neonates presented with manifestations of neonatal asphyxia at El-Minia University Hospital. They were 34 male and 16 female. All studied groups were subjected to clinical and neuroimaging assessment [cranial sonar and CT]. Cranial ultrasound was done at 2[nd] day of life, 7[th] day, 1month and 6 months follow up. CT was done at 7[th] day once. Clinical assessment was done according to Apgar score at birth. Hypoxic- ischemic encephalopathy was assessed according to both Sarnat and HIE scoring. Both clinical data and neuroimaging findings were correlated with the outcome of examined newborns. Normal cranial ultrasound at initial examination correlated well with good outcome. Cranial ultrasonography was sensitive in detection of brain edema with no statistically significant difference between it and CT at 7[th] day examination, while CT was more sensitive in detection of extra-axial blood collection. As regards late squeal, ultrasound was sensitive in detection of periventricular leukomalacia [PVL], atrophic changes and ventricular dilatation. So cranial ultrasound is ideal as a screening modality in neonatal HIE and in follow up ICH correlated with poor outcome and also early brain edema had poor outcome. 14 babies died at 6 months follow up. 20 babies developed neurological morbidity in the form of: CP [with or without convulsions] in 9 cases, delayed motor development 4 cases, delayed mental development 3 cases and 4 cases with epilepsy