Hematological Changes in HCV Patients Treated with Different Sofosbuvir-Based Regimens

Introduction: Treatment of HCV with direct acting antiviral agents (DAAs) with the different regimen dramatically changed the outcomes of the disease beside its eradication. In the same time hematological concerns as anemia, thrombocytopenia, and leucopenia were a major factor before initiation, or during treatment with the antiviral drugs.Aim: To demonstrate hematological changes during and after treatment with different regimen of DAAs.Methods: Follow up the hematological changes before, during and after treatment for 100 patients with chronic HCV treated with five different sofosbuvir-based regimen; using interferon, ribavirin, simeprevir and daclatasvir.Results: There are no similar linear changes regarding anemia, leucopenia or thrombocytopenia, however, combination therapy using sofosbuvir with simeprevir or daclatasvir significantly increase platelets count, WBCs, and hemoglobin level during and after end of treatment, versus regimens uses sofosbuvir with ribavirin and or interferon that showed significantly decreased hematological values during and after treatment.Conclusion:Sofosbuvir-based regimen has favorable hematological changes in patients with chronic HCV infection during and after treatments especially with sofosbuvir and daclatasvir

Prevalence of pulmonary mycosis in cases of chronic obstructive airway diseases

PuImonary mycosis is not an uncommon finding in patients complaining of chronic obstructive airway diseases. Corticosteroids therapy enhances the infection. Patients with tracheo-bronchitis are also infected but to a lesser extent when compared to the former group. Aspergillus spp. were the predominant fungi isolated, they were also isolated from patients' house dust

Study of some factors affecting the coagulant activity of cryoprecipitate

The effect of type of anticoagulants and time elapsed between donation and cryoprecipitation on the coagulant activity of cryoprecipitate were studied. A total of 90 blood units from healthy volunteers with blood group [A] were used for the test. Factor VIII content was higher in case of citrate phosphate dextrose. CPD being 97.4 +/- 21 and only 47 +/- 11.9 in case of the anticoagulant Acid - citrate dextrose. CPD blood separated after one hour, 2 hours and 3 hours showed factor VIII consents of 95.6 +/- 16, 91.1 +/- 15 consecutively. Better yield of factor VIII can be obtained if plasma is prepared as soon as possible after donation and the use of CPD as anticoagulant

Comparison of oesophago-gastroscopy, barium meal and ultrasound in the diagnosis of gastro-oesophageal reflux in adults

In a trial to compare ultrasound examination with oesophago- gastroscopy and barium meal in the diagnosis of gastro-oesophageal reflux disease [GERD], sixty two patient with suspected GERD were exposed to a complied history of illness and clinical examination. Oesophago-gastroscopy, barium meal and ultrasound examination were carried out on 45 patients, who volunteered to complete the tests. In 23 cases, there was an equivocal agreement between the different ways of diagnosis. In 2 cases, the diagnosis was confirmed only by Endoscopy. In 5 cases, the diagnosis was positive only by barium and in 2 cases, the diagnosis was only positive by ultrasound examination. Ultrasound has an important role in the diagnosis and follow up of adults patients with gastro-oesophageal reflux disease

study of some risk factors for hypertension in diabetic patients at Suez governorate

Three hundred and thirteen unselected persons, 150 diabetic and 163 non diabetics, aged above 30 years were surveyed in this study. Full history, complete clinical examination and analysis for blood sugar and cholesterol were done for all cases. It was found that, the prevalence of hypertension in diabetic group was 37.3% and among non diabetic it was 13.4% [P<0.001]. Diabetic female patients were affected with hypertension higher than diabetic male [39% and 23.5% respectively]. The prevalence of hypertension increased with the increase of the duration of diabetes. Also, there is a positive correlation between blood glucose level and mean systolic blood pressure. Finally, the prevalence of hypertension among obese diabetic patients was higher than obese non diabetics [p<0.05]. Also, obese diabetic female patients developed hypertension [44%] more frequent than obese diabetic male patients [21%]

prevalence of diabetic retinopathy, nephropathy and peripheral neuropathy in diabetic patients in Suez governorate

Diabetes mellitus is one of the most formidable of diseases. In this study we try to find out the prevalence of retinopathy, nephropathy and neuropathy among diabetic patients. 120 diabetic patients were included in our study. Full history, thorough clinical examination, urine analysis for proteinuria and fasting blood sugar level was done for each subject. It was found that 5% of studied group were well controlled, 27.5% were fairly controlled and 62.5% are poorly controlled. The prevalence of retinopathy was 35.8%, neuropathy was 26.7% and peripheral neuropathy was 53.3%. There was a positive correlation between retinopathy and nephropathy. The highest prevalence of these complications was in poorly controlled group. There was association between blood glucose level and prevalence of these complications. Also, there was association with the disease duration. So, diabetic patients are in need for great follow up and simplified methods for monitoring their blood sugar

Effect of oral propranolol on portal and splenic vein diameters in cases of chronic liver diseases

Different drugs had been tried to decrease portal venous pressure and different methods were utilized to study the portal venous system. In this study 32 patients 26 males and 6 females were included in this test. Thorough clinical examination and ultra-sound examination were preformed before and after two weeks of propranolol [20 mg t.d.s], there was a significant decrease in portal vein diameter after propranolol administration for two weeks from 16.4 to 14.2 mm. There was also significant decrease in the diameter of splenic vein from 16.8 to 15.3 mm. There was no significant changes in hepatic dimensions and splenic length. Also there was no significant changes in diameter of portal vein with normal respiration and valsalva maneuver during ultra-sound examination. Propranolol causes reduction in portal venous pressure but its efficay to prevent bleeding from esophageal varices needs further investigations