ABSTRACT
A total number of 55 Egyptian cattle were used. Forty animals from them were found to be affected with liver fluke as revealed by presence of parasitic ova during routine of fecal examination. According to the severity of clinical sings and fecal egg count the infested cattle were divided into two groups; the first group contains 17 animals suffering from acute fascioliasis, while the second group [23 animals] showed signs of chronic fascioliasis. The rest of the animals were apparently healthy and proved to be parasitic free, used as control groups. The results denoted the importance of serum transaminases in diagnosis of acute liver disease, while lactate dehydrogenase is a useful indicator in diagnosis of both acute and chronic liver damage. Moreover, fecal egg counts help in diagnosis and detection to the severity of the infection