ABSTRACT
The present work was carried out on 20 healthy subjects, they were divided into two groups. Group I consisted of 10 subjects ranging in age from 25 to 35 years. Group II consisted of 10 healthy subjects ranging in age from 70 to 80 years. All subjects were submitted to full general and abdominal examination, urine analysis, ECG, blood sugar were within normal range. Creatinine clearance was performed to all subjects. The results showed that, the mean value of serum creatinine was significantly increased in group II in comparison to group I. There is no significant difference between two groups as regard concentration of creatinine in urine and urine volume per 24 hours. As regard creatinine clearance, the mean value showed that there was highly significant decrease in creatinine clearance in group II as compared to group I. The renal function including GFR as was measured by creatinine clearance deline with advancing age. The decline in GFR in old age is due to morphological changes that take place in the kidney and decline of renal blood flow