ABSTRACT
Introduction: The evaluation of the quality of life [QoL] has now become an established parameter in clinical research, including analysis of the effectiveness of medical or surgical treatment. Therefore, the treatment of gastroesophageal reflux disease [GERD] not only aims to relieve symptoms, prevent complications, minimize undesirable side effects of treatment but also improve the QoL of patients
Material and Methods: Our series includes 51 patients [23 men and 28 women] whose average age was 37 years [range 17-62], treated surgically for GERD at University Hospital Hotel-Dieu de France between 2005 and 2012. Their QoL was evaluated before and after surgery [mean follow-up 4.5 years], retrospectively, using the GIQLI Questionnaire [gastrointestinal quality of life index], which comprises 36 items covering five dimensions: symptoms, physical condition, emotions, social integration and medical treatment
Results: Before the intervention, the GIQLI score was 89 +/- 9; after antireflux surgery, GIQLI score was 113 +/- 9 [p < 0.001]. The unit-variable statistical analysis revealed that the highest GIQLI scores were correlated with the lowest BMI [body mass index]. No statistically significant difference was recorded for the age, sex, and duration of medical treatment before surgery, the surgical indication, surgical technique and the surgical approach. Statistically significant improvement was noted in the following dimensions: symptoms, physical condition, medical treatment and social integration. A non-statistically significant improvement was observed at the level of the emotional dimension. 12% of operated patients resumed a regular medical treatment against reflux, 37% have resumed medical treatment on demand and 51% of patients have never taken medical treatment after the operation. Six patients were reoperated with an overall reoperation rate of 12%
Conclusions: Antireflux surgery significantly improves QoL of patients but does not guarantee the full exemption of medical treatment. In our series, patients with a normal BMI and patients with only the classic complaints of reflux [heartburn, regurgitation, belching] are the best candidates for antireflux surgery. Better patient selection could prove to be a way to improve the results in terms of QoL