ABSTRACT
Objective: the purpose of this study was to retrospectively analyze the demographic characteristics of patients with central peripheral giant cell granulomas [CGCGs] / [PGCGs] an Iranian population
Methods: in this 38-year retrospective study, the data were obtained from records of 1019 patients with CGCG and PGCG of the jaws referred to the Department of Oral and Maxillofacial, Pathology, Mashhad University of Medical Sciences, Iran between 1972 and 2010. Information regarding age distribution, gender, location of the lesion and clinical signs and symptoms was documented
Results: a total of 1019 patients were affected by giant cell granuloma lesions [GCGLs] including 435 CGCGs and 584 PGCGs. The mean age was 28.91 +/- 18.16. PGCGs and CGCGs had a peak of occurrence in the first and second decade of life respectively. A female predominance was shown in CGCG cases [57.70%], whereas PGCGs were more frequent in males [50.85%]. Five hundred and ninety eight cases of all giant cell lesions [58.7 %] occurred in the mandible. Posterior mandible was the most frequent site for both Lesions. The second most common site for PGCG was posterior maxilla [21%], whereas anterior mandible was involved in CGCG [19.45%]. The majority of patients were asymptomatic. Patient's age, location [mandible/maxilla] and bleeding were the influential variables on the type of the lesion
Conclusion: although the CGCGs share some histopathologic similarities with PGCGs, differences in demographic features may be observed in different populations
ABSTRACT
Many mucocutaneous lesions of the oral cavity have similar clinical features and therefore the histpathologic findings are very important in correct diagnosis and differential diagnosis of each lesion. The aim of this study was to assess the agreement between clinical and histopathologic diagnoses in mucocutaneous lesions of the oral cavity during 30 years [1979-2009] in Mashhad dental School. In this retrospective study, a total of 334 patients with mucocutaneus lesions were analyzed in Mashhad dental school from1979 to 2009. Patient's data including age, gender, location, clinical diagnosis and histopathologic diagnosis were recorded. Data were analyzed through SPSS 11.5 Software. In this study, there was an agreement between clinical and histopathologic diagnoses in 295 subjects [77.5%] with oral mucocutaneus lesions. All subjects with pemphigoid and white spongy nevus showed total agreement between clinical and histopathologic diagnoses. Atrophic and pigmenteted lichen planus also showed the highest percentage of agreement in lichen planus groups. In mucocutaneous lesions, clinical, radiographic, and histopathologic findings are necessary for definitive diagnosis of mucocutaneous lesions