Analysis of survival data in thalassemia patients in Shiraz, Iran / 한국역학회지

OBJECTIVES: The survival rate of thalassemia patients has not been conclusively established, and the factors associated with survival remain unclear. This study aimed to determine the survival rate of thalassemia among patients in southern Iran and to identify the factors associated with mortality from thalassemia. METHODS: This retrospective cohort study was conducted based on a retrospective review of the medical records of 911 beta-thalassemia patients in 2014. Data analysis was conducted using the Kaplan-Meier method and Cox regression analysis. RESULTS: Overall, 212 patients (23.3%) died, and 26.8% had thalassemia intermedia. The 20-year, 40-year, and 60-year survival rates were 85%, 63%, and 54%, respectively. Both crude and adjusted analyses found that education, marital status, ferritin levels, and comorbidities were related to mortality. CONCLUSIONS: Sociodemographic and hematological factors were found to be significantly associated with the survival rate of thalassemia. Addressing these factors may help healthcare providers and physicians to provide the best possible care and to improve the survival rate.

Graft survival rate in pediatric renal transplantation: a single center experience

Renal transplantation is the best option for treatment of the end-stage renal diseases and has more advantages than dialysis. The objective of this study was to determine the ten-year graft survival rate of renal transplantation and its contributing factors among a group of Iranian patients aged 18 years or younger. In a retrospective cohort we aimed to study the ten-year graft survival rate of renal transplantation and its contributing factors among pediatric patients who have been transplanted from March 1999 to March 2009 in Shiraz Namazi Hospital Transplantation Center, southern Iran. Kaplan-Meier method was used to determine the survival rate, log rank test to compare survival curves, and Cox regression model to determine hazard ratios and to model variables affecting survival. The 1, 3, 5, 7 and 10 year-graft survival rates were 96.8, 88.8, 82.8, 78.1, 78.1 percent, respectively. Cox regression model revealed that the duration of hospitalization was one of the important factors in graft survival rate in renal transplantation. In this study, the 10 year-graft survival rate for pediatric renal transplantation was 78.1%. Graft survival was significantly related to hospital stay after the operation. Donor source, cold ischemia time, immunosuppressive drugs regimen, time to diuresis, and cause of ESRD did not influence the survival rate.

[Estimation of natural age of menopause in Iranian women: a meta-analysis study]

The mean age of menopause have been reported at the age of 51 in the world and regarding the increase in life expectancy in many countries more than a third of the life time of women i s in menopause period. The importance of menopause is due to its relationship with various diseases and quality of life. The present study was conducted to estimate the average natural age of menopause in women based on a meta-analysis study. In a meta-analysis study on all the existing articles in the natural age o f menopause in Iran, 21 articles were selected based on inclusion criteria. Begg and Egger tests fo r publication bias and Cochrane test were used to determine the heterogeneity among samples. ???? estimate of mean calculated based on Random effect model in Stata11 software. The publication bias assumption was rejected by Begg and Egger tests with significant value s equal to 0.174 and 0.446 respectively. There was a heterogeneity among samples [Q=4626.3, df=20, P<0.001]. So based on random effect model the mean age of menopause was calculated as 48.183 with 95% CI=47.457-48.91. The average age of natural menopause in Iranian women is favorable to some places of Middle East, but is less compared with developed countries and the world mean. Because of the importance of this period in women, educational programs seem to be necessary

[Survival analysis of renal transplantation and its relationship with age and sex]

Kidney transplantation is the treatment of choice for end stage renal disease that restores the patients' quality of life and reduces the morbidity and mortality rates induced by renal failure and its complications. The aim of this study is to determine the ten-year graft cumulative survival rate of renal transplantation in patients who have been transplanted from March 1999 to March 2009 in Shiraz Nemazi Hospital Transplantation Center, Iran. This is a retrospective cohort study designed to determine the organ survival rate after kidney transplantation and its relationship with age and gender of recipients and donors, during a period of 10 years [March 1999 to March 2009] in 1356 patients, Shiraz transplant center, Namazi hospital, Shiraz, Iran. Kaplan-Meier method was used to determine the graft cumulative survival rate and log-rank test was used to assessment difference between survival curves in subgroups. Mean follow-up period was 47.23 +/- 33.3 months. Ten years graft cumulative survival rate of kidney transplantation calculated by Kaplan-Meier method was 85.8% [95% CI=85.78 - 85.81]. Age of recipients and donors were showed significant relationship with survival rate of renal allograft. Renal transplantation is one of the important therapeutic strategies in end stage renal disease, and chosen the appropriate donor, can improve the graft cumulative survival rate. The based on this study results, we found no significant relationship between donor and recipients' sex with graft cumulative survival rate, but the relationship between age of donor and recipient and graft cumulative survival rate were significant