ABSTRACT
Objective: To discover the burden of focal segmental glomerulosclerosis in patients of nephrotic range proteinuria [i.e.>3.5gm/24 hours/ 1.73m[2] body surface area]
Study design: A case series study
Place and duration: At the department of Nephrology Jinnah Post Graduate Medical Centre from 1st May 2011 to 30th Nov 2011
Methodology: Patients with nephrotic range proteinuria diagnosed by 24 hours urinary protein [>3.5gm/24 hours/1.73m[2] BSA] were included. Serum creatinine, total proteins, serum albumin, 24 hour urinary proteins, creatinine clearance, coagulation profile as well as renal biopsy was performed in every patient. In renal biopsy <50% glomerular involvement with involvement of a portion of the glomerular tuft was confirmed as patients having the focal segmental glomerulosclerosis
Results: The mean age of the patients was 25.93 +/- 5.923 years. Out of 144 patients there were 38[26.38%] females and 106[73.31%] males. There were 67[46.5%] patients with focal segmental glomerlusclerosis with nephrotic range proteinuria
Conclusion: The burden of focal segmental glomerulosclerosis in patients with nephrotic range proteinuria is high