Pregnancy and valvular heart disease

To review all cases of valvular heart disease during pregnancy in a regional Saudi-Arabian population between 1993-1997, determine its incidence, contributing factors and its effect on the outcome of pregnancy. A retrospective study of 33,200 cases between 1993-1997 performed over a period of 5 years in the Department of Obstetrics and Gynecology in King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia. Most patients were Saudi nationals [83.4%]. Evidence of heart disease was detected in 166 pregnant women, an incidence of 0.5%. Valvular heart disease was present, either as a single valve involvement or in combination, in 76% of the patients. The remaining 24% were a miscellaneous group including patients with cardiomyopathies, or pulmonale and septal defects. The data collected was analyzed using Gold Stat Software Package. As a single valve disease, mitral valve involvement was predominant [94.5%], compared to aortic valve [5.5%]. The most common condition involving mitral valve was the valve prolapse [39.2%], followed by mitral regurgitation [19.9%] and mitral stenosis [16.9%]. Twenty-four percent of the pregnant women with valve disease had multiple valve involvement. Forceps were applied in 8.4% of the patients and ventouse deliveries in 1.2%. Cesarean section was performed in 3.6% of the cases, out of which 2.4% were emergency lower segment cesarean section and 1.2% were elective. No maternal or infant mortality occurred. All infants were normal and healthy with mean infant weight of 3.24 +/- 0.52 kg. Prophylactic antibiotics were administered in 83% of the patients. None of the patients, whether treated with antibiotics or not, developed infective endocarditis, Presence of valvular heart disease in our study did not appear to affect the outcome of pregnancy, but its accurate diagnosis and management dem and a greater underst and ing of cardiovascular physiology and its pathophysiology in pregnancy, labor and the puerperium. The successful management of the woman with valvular heart disease in pregnancy required complete cooperation between the patient herself, the obstetrician, cardiologist, anesthetist and other supporting medical staff, to optimize the outcome for both the mother and her baby

case of seven recurrent ectopic pregnancies

If a woman with previous ectopic pregnancy ever gets pregnant again, the risk of a repeat ectopic pregnancy is said to be 4-fold. We present a rare case of 7 recurrent ectopic pregnancies in a 39-year-old Saudi woman, together with a literature review of the reproductive performance after recurrent ectopic pregnancy

Cytogenetic investigation on fetuses from spontaneous abortions

Chromosome analysis was performed on 78 successfully cultured fetal specimens from spontaneous abortions between 12 and 24 weeks gestation. Chromosome abnormalities were found in 8% of cases. The frequency in our series is compared with the other published reports. The type of chromosomal abnormalities commonly found in spontaneous abortions, chromosomal abnormalities in relation to gestation period and maternal age are discussed. According to our information, this is the first study on the subject carried out in the central zone of the Kingdom of Saudi Arabia