ABSTRACT
Diabetes mellitus [DM] is a health concern because it leads to complications such as retinopathy. Pakistan has 6.9 million DM affected people that will be doubled by 2025
A study was designed to enumerate CD4+CD25+Treg cells in Pakistani type 2 diabetes mellitus [T2DM] patients. It was a cross-sectional case-control study that included 212 objects
The subjects having diabetic retinopathy were labeled as Group-I [30 healthy volunteers without diabetes], Group-II [30 T2DM patients without retinopathy] and Group-Ill [152 T2DM patients with retinopathy]
The percentage of CD4[+]CD25[+] Treg cells was determined by Flowcytometry
Comparison of CD4[+]CD25[+]T cells among different groups was not significant and higher percentage of Treg cells was observed in Group-II [3.07%] compared to Group-Ill [2.88%]
Age, gender and duration of diabetes may contribute while percentage of CD4[+]CD25[+]T cells and Treg cells were not associated with the development of DR in T2DM