ABSTRACT
Objective: valuating the vitamin B[1] [thiamine] on glucose homeostasis and Glycosylated hemoglobin A1 [HbA1c] in Alloxan induced diabetic rat model
Study Design: Experimental study
Place and Duration of Study: This study was conducted at the Animal House, Isra University Hyderabad from September 2014 to March 2015
Materials and Methods: 60 adult albino rats were divided into four groups; Group 1. Controls, Group 2. Rats receiving thiamine added diet, Group 3. Diabetics rats on normal diet and Group 4. Diabetic rats receiving thiamine added diet. Alloxan [120 mg/kg] was introduced intraperitoneally to induce diabetes. Vitamin B1 was given orally at 1.6 g/kg body weight for 12 weeks. Venous blood was taken from tail vein by small bore cannula at the baseline and after 12[th] week. Blood glucose and HbA1c were detected at baseline and after 12[th] week. Data was saved in proforma and analyzed on SPSS 22.0 using paired student t-test at 95% confidence interval
Results: Blood glucose and HbA1c levels were found statistically significant in groups 1 vs. 3 [p=0.0001], 1 vs. 4 [p=0.0001], 2 vs. 3 [p=0.0001], 2 vs. 4, [p=0.001] and 3 vs. 4 [p=0.024] at the end of experiment period. Significant improvement in blood glucose and HbA1c was noted in the vitamin thiamine treated rats
Conclusion: Vitamin thiamine improved the blood glucose homeostasis and reduced Glycosylated Hemoglobin A1 effectively in experimental rats. It is recommended to supplement diabetic subjects with vitamin thiamine
ABSTRACT
Objectives: this study was carried out to compare the placentae from hypertension associated pregnancies and normal pregnancies
Design: comparative study
Setting: Isra University Hospital Hyderabad Sind
Method: eighty full term placentae were collected; 40 from normal and 40 from hypertensive pregnant women. Gross features of placentae were noted and then stained for their microscopic features. Birth weight and Apgar score of the newborn were recorded
Results: the weight and surface areas of placentae were significantly low in the hypertensive group whereas thickness of placenta and number of cotyledons were almost same in hypertensive and control groups. Microscopically increased number of syncytial knots, chorionic villi with excessive collagen was observed in placentae of hypertensive women. In hypertensive group birth weight of neonates was significantly low than control group while difference in APGAR score between two groups was statistically insignificant
Conclusion: hypertension during pregnancy is associated with remarkable changes in the placentae
ABSTRACT
Objectives: to assess the sleep pattern among teaching faculty of Isra University using Pittsburgh sleep quality index and Epworth sleepiness scale
Design: descriptive study
Setting: Isra University Medical College and Hospital Hyderabad Sindh
Method: eighty three members of teaching faculty of Isra were randomly selected for this study. These were divided into 02 groups, basic and clinical teachers. All were given instructions to fill the questionnaires of Pittsburgh sleep quality index and Epworth sleepiness scale. These were then collected and analyzed
Results: among faculty members mean Epworth score was 8.2 +/- 0.58 and mean Pittsburgh score was 5.7 +/- 0.54. Both the scores in two groups were within normal range. In males Epworth and Pittsburgh scores were 8.3 +/- 0.85 and 5.6 +/- 0.72 respectively while in females these scores were 8.01 +/- 0.73 and 6.67 +/- 0.86. Pittsburgh score was significantly higher in females as compared to males
Conclusion: it is concluded that sleep as assessed by using Pittsburgh sleep quality index and Epworth sleepiness scale was within normal range among the faculty members of Isra University. Female faculty members had significantly higher Pittsburgh score as compared to male faculty members signifying worse sleep quality
ABSTRACT
Objectives: this study was carried out to evaluate homocysteine as a risk factor for ischemic Stroke
Design: descriptive study
Setting: isra University and Liquate university of Medical and health sciences Jamshoro [LUMHS]
Study design: twenty five diagnosed cases of ischemic stroke were selected from different wards of two hospitals. Twenty five healthy age matched persons were taken as controls having no risk factors for stroke. Serum homocysteine level was determined by enzyme immunoassay using commercially available kit
Results: serum homocysteine level in patients with stroke was 14.0 +/- 1.9 [micro]mol/Lit and in healthy controls it was 9.0 +/- 0.58 [micro]mol/Lit. There was statically significant difference [p < 0.05] in the homocysteine level between the two groups yet the level was within normal range
Conclusion: serum homocysteine level is significantly increased in patients with ischemic stroke as compared to the normal healthy individuals having no ischemic stroke risk factors
ABSTRACT
To assess the sleep pattern of students of Isra University using Pittsburgh sleep quality index and Epworth sleepiness scale. Descriptive study. This study was conducted at Isra University medical college Hyderabad Sind from Jan 2010 to June 2010. One hundred medical students of various batches of Isra University were randomly selected for this study. There were 57 females and 43 males. All were given instructions to fill the questionnaires of Pittsburgh sleep quality index and Epworth sleepiness scale. These were then collected and analyzed. Among the students mean Epworth score was 8.37 +/- .342 and the mean Pittsburgh score was 5.99 +/- 0.322. Pittsburgh score was above the reference value. There was no difference in these scores between male and female students. In 34% students, Epworth score was above 9 and in 55% students Pittsburgh score was above 5. Both scores were higher in more female students than males. 26% students had less duration of sleep and 13% had difficulty in daily routine due to insufficient sleep. It is concluded that Sleep as assessed by using Epworth sleepiness scale was within normal range. Mean Pittsburgh sleep quality index was above normal range indicating poor sleep quality. Duration of sleep was mainly affected
Subject(s)
Humans , Male , Female , Sleep Wake Disorders , Sleep , Students , Prospective Studies , Surveys and QuestionnairesABSTRACT
Objective: To determine the prevalence of musculoskeletal complications and recommend remedies to computer users at ISRA University, Hyderabad
Design:Descriptive cross-sectional study
Place and Duration: This study was conducted from October 2009 to March 2010 at ISRA University, Hyderabad
Methodology: One hundred computer users [54 males and 46 females] of Isra University were enrolled in this study. Through a questionnaire, data were collected and statistically evaluated using the Chi-square test. Furthermore, remedies [rest, physiotherapy, nonsteroidal anti-inflammatory drugs [NSAIDS] and muscle relaxant] were prescribed for relief, according to the grading of complications
Results: The frequency of musculoskeletal complications in either group [male or female] was 52.63% in those who had been in contact with computers for less than or equal to 2 hrs, 68.18% between 2-4 hrs, 81.48% between 4-6 hrs, and 93.75% more than 6 hrs, respectively. The frequency of musculoskeletal complications [neck pain, low backache, shoulder pain, and elbow and wrist pain] was graded according to a scale of pain ranging from grade I to grade V with respect to the number of hours spent with computers
Conclusion: The results of the study revealed that most subjects had complaints of musculoskeletal complications directly proportional to the extensive use of a computer. The pattern observed in evaluating pain on a grading scale suggests opportunities for remedies