ABSTRACT
Objective: To discover the frequency and presence of multiple antimicrobial resistant strains of Pseudomonas aeruginosa [P.aeruginosa] in patients with Post tuberculosis bronchiectasis in Baluchistan
Design: A prospective descriptive study
Place and duration: this study was done in Pulmonology and tuberculosis outpatient department [OPD] of Fatimah Jinnah Chest Hospital and Rehan Hospital Quetta Pakistan from 1st October 2011 to 1st April 2012
Methodology: The samples were obtained from post tuberculosis patients [n=60, Age = 40+ years] suspected of bronchiectasis who were subjected to spirometry test, Mueller Hinton sensitivity testing, oxidase test and disk-diffusion method to find out frequency and multiple drug resistance of P. aeruginosa
Results: Our results confirmed the association of chronic P. aeruginosa infection with poor lung function. It is not clear whether P. aeruginosa caused the accelerated decline in lung function or it was just a marker of those whose lung function was already declining rapidly. The antibiotic susceptibility testing confirmed the presence of resistant strains of the P. aeruginosa most of which were mucoid strains. It proved that a single antibiotic therapy is not a good treatment for patients with P. aeruginosa infection in airways
Conclusion: Bronchiectasis is more frequently encountered in middle-aged and elderly persons and resistant strains of P. aeruginosa are highly prevalent in these patients
ABSTRACT
Objective: To evaluate the efficacy of combined therapy of meglumine antimoniate and co-trimoxazole in cutaneous leishmaniasis [CL]
Methods: 180 patients with active lesions of CL, confirmed by fine needle aspiration cytology [FNAC] were treated with combined therapy of meglumine antimoniate [Glucantime] and co-trimoxazole [Septran] for 20 days
Results: Out of 180 patients, 160 [88.9%] were cured. A few patients reported nausea, vomiting, glossitis, skin rashes and folate deficiency
Conclusion: The combined therapy of meglumine antimoniate [Glucantime] and co-trimoxazole [Septran] is more effective than the previously reported combined therapies
ABSTRACT
Background: Pancytopenia is a recognisable haematological problem with common categorises diagnosis but best possible diagnostic approach is still to be defined. Objective: The aim of this study was to determine the frequent causes and clinical presentation of pancytopenia in relation to age and sex in different ethnic groups of two national [Pakistani and Afghan] living in Baluchistan province. Methods: This is a cross sectional descriptive type of study was carried out on patients [n=180] for two years [July 2009June 2011]. Cases were successively registered in 2 provincial government hospital and 2 private clinics in Quetta with diagnosis of pancytopenia. Results: The most frequent causes of pancytopenia in both national ethnic groups were malaria [29.44%] fallowed by tuberculosis [17.22%], leukaemia [16.67%], aplastic anaemia [13.33%], hepatitis [12.22%], other diseases [7.22%] and iron deficiency anaemia [3.89%]. Overall, 63.89% male subjects were observed pancytopenia as compared to 36.11% female patients. The results also showed that patients with age >41 years were highly [50%] affected by pancytopenia followed by 2140 years [30.66%] and <20 years [19.44%]. Moreover, leukaemia cases were observed significantly higher in Afghan subjects [>41 years]. The most common symptom of patients was [71.11%] fever followed by Pallor [42.22%], fatigue [38.33%], weight loss [26.11%] and dizziness [25.56%]. Leukaemia and aplastic anaemia were found to be the most serious causes of pancytopenia in Afghan ethnic group. Conclusions: Malaria, tuberculosis, aplastic anaemia, and leukaemia were the leading causes of pancytopenia in Pakistani and Afghan ethnic groups. Severe pancytopenia has significant relation with the clinical conclusion and can be used as a prognostic marker