ABSTRACT
The effect of jurak smoke condensate on the activities of alkaline phosphatase, glucose 6-phosphatase, 5-nucleotidase, and cholinesterase of mouse liver and small intestine was investigated. Jurak smoke condensate was administered orally by stomach tube five times weekly over a three-month period. Fifteen animals were used at 1,2, and 3 months after the start of the administration, with 5 animals killed on days 1,5 and 9, and the liver and small intestine removed for enzyme assays. The activities of all four enzymes, which are known to be sensitive to toxic agents, were significantly affected. These results indicate that the low content of tobacco leaves in jurak paste and the filtration of the smoke by water in the sheesha reservoir are not sufficient to make the smoke inhaled by smokers risk free