ABSTRACT
Objective: to assess the pattern of plasma lipoproteins in CAD patients including comparison between diabetic and non-diabetic subgroups
Methods: this case control study was conducted at National Institute of Cardiovascular Diseases [NICVD] Karachi on patients admitted for CABG from June, 2000 to June, 2001. A total of 100 patients and 100 healthy subjects were enrolled during the study. 38 patients [38%] were diabetic with mean age of 46.16 years and 62 patients [62%] were non-diabetic with mean age of 45.26 years. Serum lipids, apolipoproteins A, apolipoproteins B and Lp [a] of each subject were analyzed. One way ANOVA and 95% confidence interval for mean were applied to find the association of CAD with age, BMI, glucose, cholesterol, triacylglycerol's, HDL-c, LDL-c, and Lp [a]
Result: CABG patients had significantly higher blood TAG levels than controls. Similar results were observed for HDL-c, which was significantly lower when compared with control subjects. Apo-B and Lp [a] in controls were significantly lower than both diabetic and non-diabetic CAD patients. The level of Apo-B in diabetic CAD was significantly higher when compared with control subjects
ABSTRACT
Diabetes mellitus with its long term complications is a common problem in our country. Arterial hypertension is commonly found in association with diabetes mellitus. As hypertension constitutes a major cardiovascular risk factor, it is essential to diagnose and treat elevated blood pressure as a part of a multiple risk factor intervention strategy in diabetic patients. There is relatively limited data available of diabetic hypertensive patients with regard to its prevalence and associated nephropathy in our country. This hospital based small size prospective study of 1.86 diabetics, comprised 42 patients with IDDM and 144 patients with NIDDM, of both sexes and ages between 18 to 60 years. The main objective of this study was to evaluate the prevalence of hypertension in diabetic patients and its development and progression of diabetic nephropathy. The overall frequency of arterial hypertension was higher [47%] in NIDDM group as compared to IDDM which was 24%. In NIDDM group, the prevalence of normoalbuminuria 49% while microalbuminuria was 33% and macroalbuminuria was 18%, while in IDDM group, the of normoalbuminuria was, 38%, microalbuminuria 33% and macroalbuminuria was 29%. In NIDDM group, the frequency of arterial hypertension was 37% in norm oalbuminuric group, while 52% in microalbuminuria and 61% in macroalbuminuric patients. The IDDM group showed a high frequency of raised arterial hypertension with onset of clinical nephropathy being 17% in normoalbuminuric, 30% in micro and 65% in macroalbuminuric patients. In order to decrease the disability and to prevent, induced or accelerated by hypertension, easy detection and treatment is mandatory. The JNCVI, criteria approved by American Diabetic Association [ADA] are the most sensitive detectors of the early harbingers of potentially serious diabetic complications