ABSTRACT
Background: Anemia is defined as a decrease in the hemoglobin concentration of blood, which accordingly decreases the oxygen-carrying capacity of red blood cells such that they are unable to meet the body's physiological requirements. Numerous reports have specified that anemia customarily occurs in patients with diabetes with renal insufficiency whereas limited studies have described the occurrence of anemia in people with diabetes prior to indication of renal impairment. Other studies have similarly recognized anemia as a risk factor for the need for renal replacement treatment in diabetes. Understanding the pathogenesis of anemia allied with diabetes can lead to the development of interventions to optimize results in these patients
Purpose: The purpose of this study was consequently to determine the pervasiveness of anemia among patients with type 2 diabetes
Materials and Methods: A total of 50 [25 with type 2 diabetes and 25 controls] participants were enlisted for the current study. Participants' blood samples were analyzed for fasting blood glucose, full blood count and renal function tests among others. The pervasiveness of anemia was then determined statistically
Results: A high incidence of anemia was perceived in the cases. Of the patients with diabetes, 85% had a hemoglobin concentration that was significantly less [males 10.88 +/- 1.78 and females 10.32 +/- 1.52] compared to that of controls [males 14.16 +/- 1.82 and females 12.49 +/- 1.11]. A significantly increased fasting blood glucose, urea, sodium, potassium, and calcium ions were observed in the cases [8.02 +/- 1.28, 5.21 +/- 2.01, 141.08 +/- 7.01, 4.84 +/- 0.49 and 1.51 +/- 0.28 respectively] as compared to the controls [4.57 +/- 0.52, 3.61 +/- 2.09, 134.86 +/- 6.75, 4.38 +/- 0.61 and 1.31 +/- 0.31 respectively]. Finally, a significant association between hemoglobin concentration and fasting blood glucose was also observed in the cases
Conclusions: The findings suggest that a high incidence of anemia is likely to occur in patients with poorly controlled diabetes and in patients with diabetes and renal insufficiency
ABSTRACT
Background: A deficiency of Vitamin D not only causes poor bone mineralization but also has been implicated in many other chronic diseases. Recent studies have suggested a relevance of vitamin D to reproductive physiology. Moreover, recent evidence is establishing to support the hypothesis that vitamin D status may contribute to the development of metabolic disturbances in PCOS
Aim of the study: To investigate the relationship between Vitamin D level and polymorphisms related to metabolic disturbances particularly Insulin resistance in women with PCOS
Methods: A review of the scientific literature [PubMed Search 1960 to 2017] Pubmed, Embase and CENTRAL were searched to identify randomized controlled trials that investigated The Correlation between Depression and Folate Deficiency as the primary outcome. Identification of papers and data extraction were performed by two independent researchers. We searched for relevant trials in the Cochrane Library, MEDLINE [from 1960], Embase [from 1960], and ongoing trial databases; all searches current to October 2017
Results: Eight studies were included enrolling 1225 women; 779 patients with depression and 446 control subjects. Univariate regression analyses of the weighted means indicated a significant correlation between vitamin D and IR predictability in both PCOS and control women. However, the significance was neutralized after factoring BMI in PCOS women
Conclusion: There is a growing body of evidence suggesting an inverse association between vitamin D status and metabolic disturbances in PCOS in the current literature yet heterogeneity of the conducted studies made it difficult to come out with a solid conclusion. Nevertheless, normalization of vitamin D levels is recommended generally and especially for PCOS patients