Clinical failure of ceftriaxone treatment in a patient with penicillin resistant pneumococcal meningitis.

A case of meningitis caused by penicillin resistant Strep.pneumoniae is described for the first time in our hospital. This case also showed treatment failure with Ceftriaxone. Patient was successfully treated with Imipenem. It is recommended that routine screening for penicillin resistance in meningeal isolates be done and in such instances, the MIC levels for third generation cephalo-sporins also be performed to detect resistance of any type