ABSTRACT
Objective: We aimed to investigate the oxidative stress status in children with beta-thalassemia major [beta-TM] by measuring native thiol [SH], disulfide [SS] and total thiol [SH + SS] plasma levels
Methods: This study was carried out from November 2017 to March 2018 at the Pediatric Hematology Clinic of the Harran University Medical Faculty Hospital. Blood specimens were collected from 100 participants, including 50 beta-TM patients and 50 controls, and SH, SS and SH+SS levels were detected through a newly developed method
Results: SH, SS, SH+SS levels and SS/SH ratio were markedly higher in beta-TM patients than in controls. In beta-TM group, SH and SH+SS levels were positively correlated with age, albumin and total bilirubin. Serum ferritin level was positively correlated with SH, SH+SS, aspartate transaminase and alanine transaminase
Conclusions: We found that the SS/SH ratio was high in patients with beta-TM, which shows increased oxidative stress. This ratio may be considered as a tool for the determination of oxidative status in such patients due to easily calculate, suitable for routine use and economical
ABSTRACT
This study aimed to evaluate serum selenium levels and mean platelet volume in children who experience simple febrile convulsion. The study comprised 42 patients diagnosed with simple febrile convulsions and a control group of 30 healthy children. Blood samples were taken following a febrile convulsion. Selenium levels in the serum of both the patients and control subjects were measured with the hydride formation method on an atomic absorption spectrometry device and mean platelet volume was evaluated. When the mean values of the febrile convulsion patients were compared with those of the control group, the mean selenium levels and thrombocyte count were found to be statistically significantly low [P=0.002, P=0.01] respectively] and the mean platelet volume values were statistically significantly high [P=0.002]. While low serum selenium levels cause the onset of a febrile seizure in patients with simple febrile convulsion, it is thought that the increased mean platelet volume shows infection activity causing febrile convulsion