Photodynamic therapy with verteporfin for corneal neovascularization

To investigate the efficacy of photodynamic therapy [PDT] with verteporfin for the treatment of patients with corneal neovascularization. Retrospective interventional case series of 33 eyes of 32 patients with stable corneal neovascularization who were refractory to conventional treatment and were treated with single photodynamic therapy with verteporfin [6 mg/m [2]] at King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia between January 1, 2007 and December 30, 2009. The mean age was 40.7 +/- 19 years [range 16-76 years]. The mean follow-up for all patients was 13.1 +/- 5.5 months [range 6-24 months]. The average amount of corneal neovascularization was 2.7 +/- 1.9 [1-10]. Corneal neovascularization was deep in 19 [57.6%] eyes and superficial in 14 [42.4%] eyes. Preoperative and postoperative visual acuity and intraocular pressure, and clinical outcome of the treatment were assessed. Statistical analysis was performed to investigate the association to potential risk factors, to assess the change in data and determine the risks for failure. A P-value less than 0.05 was statistically significant. At the last follow-up visit, 22 [66.7%] eyes showed a decrease in corneal neovascularization and evidence of vascular thrombosis. Complete vascular occlusion was achieved in 14 [42.4%] eyes, partial occlusion was achieved in 8 [24.2%] eyes, and the vessels were patent in 11 [33.3%] eyes. The corneal neovascularization score and depth of the vessels were found to be significant risk factors for failure [P=0.0001 and 0.046, respectively]. However, the diagnoses or causes of corneal neovascularisation were not statistically significant. No significant systemic or ocular complications associated with photodynamic therapy were observed. Photodynamic therapy with verteporfin was effective for the treatment of corneal neovascularization in the majority of the cases in this study

Nodular episcleritis in a young patient

To report a case of nodular episcleritis at the limbus associated with corenal deposits in a young patient. Observational case report. A 16-year-old Saudi girl developed a pinkish-white, soft, well-demarcated mass, 6 x 5 mm in size and 1mm in height, in the superonasal limal area of the right eye. It was associated with yellowish deposits in the adjacent cornea. histopathological evaluation of the excised lesion revealed chronic inflammation in the deep layer of the episclera with infiltration by lymphocytes and epithelioid cells, in addition to capillary proliferation. subsequently, the patient didn't develop any systemic manifistation or recurrence during the one-year follow-up period. Although nodular episcleritis tends to occure in an older age group, it can also present in young patients. Surgical excision can result in an excellent clinical outcome

fixed and dilated pupil [Urrets-Zavalia Syndrome] after penetrating keratoplasty for keratoconus

A fixed and dilated pupil [Urrets-Zavalia Syndrome] is an uncommon postoperative complication after penetrating keratoplasty [PKP] and other intraocular procedures. Although the clinical features have been well described, precise etiology of this syndrome is unknown. We describe a case of fixed dilated pupil [Urrets-Zavalia Syndrome] following PKP for keratoconus encountered at the King Khaled Eye Specialist Hospital in Riyadh, Saudi Arabia