Subarachnoid lavage following inadvertent intrathecal injection of tranexamic acid

Tranexamic acid (TXA) is a commonly used antifibrinolytic drug during surgical procedures to reduce blood loss. An Inadvertent intrathecal injection of TXAmay lead to serious side effects including seizures and ventricular fibrillation with reported fatalities. We report a case of an inadvertentintrathecal injection of TXAwhich occurred as a result of similarities in appearance between TXAand heavy bupivacaine ampoules. The patient had subarachnoid lavage after experiencing back pain, systemic hypertension followed by generalized tonic clonic seizures

Glycaemic Evaluation of Murraya koenigii in Alloxan-induced Diabetic Rabbits.

Background: Study was aimed to evaluate the antidiabetic activity of Murraya koenigii, a traditional medicinal plant (Curry leaf) in normoglycemic and alloxan-induced diabetes rabbits. Methods: Antidiabetic activity of aqueous extract of M. koenigii in 100, 200 300 mg/k doses was determined by estimating blood glucose before and at 1, 2, 4, 8, 24, and 72 hours post treatment intervals in treated rabbits. Results: Aqueous extract of Murraya koenigii showed a dose dependent antidiabetic activity with maximum effect established at 300 mg/kg. The extract also exhibited a significant (p<0.05) dosedependent hypoglycemic effect on normal and alloxan-induced diabetic rabbits. Conclusion: Murraya koenigii causes a reduction in blood glucose. This hypoglycemic property supports-its usein folkloric medicine as an antidiabetic agent and thus suggests a place for it in nutritional therapy in the management of diabetes mellitus and thus as an oral hypoglycaemic agent.