ABSTRACT
Kinetic methods [fixed concentration, rate constant and fixed time] for the sensitive and accurate spectrophotometric microdetermination of sertraline basic drug have been described. The methods are based on the reaction between sertraline and iodine in 1,2-dichloroethane as a suitable medium. At a fixed time of 10 min, the spectrum of the formed inner and / or outer-sphere complexes [Drug. I+] I- / and or [Drug I2] is measured at a suitable selected lambdamax = 396 nm. The concentration of sertraline drug, in its pure form is calculated using the calibration equation for the fixed time method. Beer's law was obeyed in the concentration range of 1.6-48 microg ml[-1] and the recovery in average was 99.85%. The relative standard deviation RSD [n = 7] at 8 micro g ml[-1] is 0.65% and at 24 micro g ml[-1] is 0.88% within-day, and at 10 micro g ml[-1] is 0.67% and at 20 micro g ml[-1] is 0.84% for between-day, respectively. Therefore, the intera- and inter-day RSD values indicated the ruggedness of the fixed time kinetic method. The method is suitable for quantitative determination of sertraline in the concentration range of 6-20 microg ml[-1] in pharmaceutical formulation [Lustiral] after its separation as a basic form out of drug formulation additives like starch, glucose, ... etc without interference. The results obtained agreed well with the data obtained by an official method. The determination of sertraline by fixed concentration and rate constant methods is feasible with the calibration equations obtained but the fixed time method is more accurate