ABSTRACT
Background: To verify the hypothesis that the incidence of chromosomal abnormalities increases in babies conceived by different assisted reproduction procedures. The availability of the umbilical cord blood encouraged us to study this hypothesis via this method
Materials and Methods: This is a descriptive study, umbilical cord blood samples of assisted reproductive technology [ART] children were analyzed with standard cytogenetic techniques [G banding]. Karyotyping was possible in 109 cases
Results: The number of abnormal cases was four [3.7%], among which, three cases [2.8%] were inherited and only 1 case [0.9%] was a de novo translocation. In total, the incidence of de novo chromosomal abnormalities was in the range observed in all live births in the general population [0.7-1%]
Conclusion: No significant difference in the incidence of chromosomal abnormality was found between ART and naturally conceived babies. To date, several studies have examined the medical and developmental outcome of ART children and still have not reached a definite conclusion. Genetic counseling is recommended as an integral part of planning of treatment strategies for couples wishing to undergo ART
ABSTRACT
The aim of this study is assessment of effects of different assisted reproductive techniques [ART] like in vitro fertilization [IVF] and intra cytoplasmic sperm injection [ICSI] on prelinguistic behavior of infants conceived by these techniques. In this descriptive, cross sectional study, prelinguistic behavior of 151 full term ART infants of Royan Institute have been assessed in Children's Health and Development Research Center of Tehran from August 2007 until August 2009. Questionnaires were completed by parents at 9 months old. The questionnaire was standard according to Early Language Milestone Scale-2 [ELM-2]. Data were analyzed by SPSS version 16 and using chi-square test. Twenty-two [14.5%] of infants were conceived by IVF and 129 [85.4%] by ICSI. Number of infants with delay in reduplicated babbling in ICSI method was more than in IVF. There was only a significant difference in echolalia delay in the two sexes. Echolalia was delayed more in boys. Delay of reduplicated babbling was more in infants of younger mothers. There was no relation between speech and language defect of parents and infants. This study showed that prelingustic behavior of ART infants are affected by kind of ART method, infant sex, and mother's age at the time of pregnancy