ABSTRACT
Neisseria Meningitis and streptococcus pneumoni being the most common organisms in bacterial meningitis, penicillin resistance is emerging fast in them worldwide. As there are very few studies in this regard a study was done at Abbasi Shaheed Hospital to determine the comparative yield of causative organisms along with observing penicillin resistance in these organisms causing pyogenic meningitis. Materials And One hundred and twenty patients were enrolled out of which 50 were selected for this study. Among these 38 were males and 12 were females. Lumber puncture was done on all of them and C.S.F was sent for Gram staining and culture. Result: Neisseria meningitidis and Streptococcus Pneumoniae were responsible for 48% and 40% of cases respectively. Haemophilus influenzae showed a very low occurrence rate. of 8%. While 16.25% of isolated pneumococcus were resistant to penicillin. Majority of cases occurred in young adults and in winter season. Neisseria meningitidis and Streptococcus Pneumoniae are the most frequent causative organisms. The Penicillin resistance is significantly high [P<.000] among pneumococcal strains