Nonalcoholic Fatty Liver Disease [NAFLD]

Background: Nonalcoholic fatty liver disease is the most frequent cause of liver disease across the world. Its pathophysiology is considered multifaceted and is controlled by numerous mechanisms comprising environmental, metabolic, genetic, and gut microbial factors. Diagnosis of nonalcoholic fatty liver disease poses a challenge owing to its subtle and non-specific presentation

Methodology: we conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE from January 1987 to March 2017. The following search terms were used: fatty liver disease, nonalcoholic liver disease, chronic liver disease, diagnosis and management of liver pathology

Aim of the work: In this study we aimed to understand about the pathophysiology, diagnosis, management and prognosis of nonalcoholic fatty liver disease

Conclusion: More studies must be done to formulate a more definite and reliable diagnostic method. General practitioners and specialists must be informed of the possible manifestation sings to keep higher degree of suspicion. Once NAFLD is established, frequent follow-up and proper management can reduce complications and improve prognosis

review of the pathogenesis of pediatric asthma and the effect of Leukotriene modifiers in pediatric asthma management

Background: asthma is the most common chronic illness that affects children. It is described by chronic airway inflammation, remodeling of the airway wall, and airway hyper-responsiveness to non-specific spasms in response to stimuli causing a reversible airflow obstruction. Leukotrienes are one of the primary chemical mediators of inflammation in asthmatic airway, therefore leukotriene modifiers are an important class of drug for treating asthma

Methodology: we conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE, January 1981, through February 2017. The following search terms were used: asthma pathophysiology, chemokines, leukotriene, and leukotriene modifiers, Montelukast in asthma management

Aim: our aim was to understand in depth the pathophysiology of pediatric asthma, and to study the effect of leukotriene modifiers in asthma management

Conclusion: for management of pediatric asthma, the leukotriene modifiers play a key role. New studies have shown that they could help in reducing dose and dependency on inhaled corticosteroid for maintenance, and decrease the need of systemic steroids in exacerbation. Leukotriene modifiers can have a positive impact on future asthma management and requires more studies to be done in this subject