ABSTRACT
Objective: To observe the protective effect of Curcuma Longa in Nitro-Methane Sulfonamide induced hepatotoxicity
Study design: Experimental Case Control Study
Place and duration: Departments of Physiology and Postgraduate Research Lab of ISRA University Hyderabad, from 1st June 2012 to 31st December 2012
Methodology: 40 male albino Wistar rats were equally divided into four groups of 10 each. Group A used as the control group and was fed the normal rat chow for 09 days. Group B was fed with Nitro-Methane sulfonamide for 09 days followed by Curcuma Longa for next 09 days. Group C was given Curcuma Longa for 09 days followed by Nitro-Methanesulfonamide for next 09 days. Group D was given Nitro-Methane sulfonamide in combination with Curcuma Longa for 09 days. After 24 hours of feeding, blood samples from groups A and D were taken from dorsal vein in the tail of rats for biochemical analysis of serum levels of ALT, AST, ALP and a-GT at days 01 and 09 and for groups B and C blood samples were collected at day 01, day 09 and day 18
Results: The analysis showed that prevention from the Nitro-Methane sulfonamide induced hepatotoxicity by the Curcuma Longa administration was observed after 18 days with a p value < 0.012, and Pearson's correlation for regression at - 0.06 and -0.07
Conclusion: The results have clearly proven that Curcuma Longa in powdered form as used in the daily diet in our part of world acts as a homeostatic booster against a huge variety of stressors especially "over the counter" drug induced hepatic stresses