ABSTRACT
Objective To investigate the clinical significance and level changes of miR-126 on hemodialysis patients.Methods 60 cases from hemodialysis were divided into patients with coronary artery disease (35cases),including single coronary artery lesion (12cases) and two coronary artery lesion (13cases) and coronary multivessel lesions (10cases),or no coronary artery disease (25cases).They were detected miR-126 expression by real-time PCR.Results There were obvious differences of miR-126 expression levels between patients and normal group (F=5.32,P＜0.05),and obvious differences of A groups and B groups,or C groups (t=6.32 ～ 8.35,all P＜0.05).Among single coronary artery lesion,two coronary artery lesion,and coronary multivessel lesions,there were obvious differences of miR-126 expression levels (F=6.15,P＜0.05).The single coronary artery lesion had a higher miR-126 expression levels than those of two coronary artery lesion and coronary multivessel lesions (t=8.41～11.65,all P＜0.05).Conclusion Detection of miR-126 expression levels could be related to hemodialysis with coronary artery disease.