Subject(s)
Humans , Antibodies, Anticardiolipin , Antiphospholipid Syndrome/diagnosis , Venous Thrombosis/etiology , Abortion, Spontaneous/etiology , Anticoagulants/therapeutic use , Clinical Diagnosis , Platelet Aggregation Inhibitors/therapeutic use , Antiphospholipid Syndrome/complications , Antiphospholipid Syndrome/drug therapy , Thrombocytopenia/etiologyABSTRACT
The prevalence of Lyme disease in Chile is unknown. To study the existence and epidemiology of Lyme Disease in Chile. One hundred eighteen patients with signs or symptoms suggestive of Lyme disease were studied. Antibodies against Borrelia burgdorferi were measured using ELISA and indirect immunofluorescence screening tests. Positive cases were confirmed with ELISA using a purified antigen and Western Blot analysis. Human biological samples and ticks were cultured in BSK-H medium. Five patients, 3 with dermatological manifestations and two with facial palsy and other neurological symptoms, had antibodies against Borrelia, measured by ELISA and indirect immunofluorescence. However, the presence of IgM antibodies by ELISA using purified antigen, was confirmed in only one case. All sera and cerebrospinal fluids were negative on Western Blot analysis. No plasma, skin, CFS or thick culture yielded Borrelia. We could not confirm the existence of Lyme disease in Chile. Positive screening with negative confirmatory test suggests false positive non-specific reactivity or that local Borrelia are antigenically different compared to North American strains
Subject(s)
Humans , Male , Female , Child, Preschool , Adolescent , Adult , Middle Aged , Lyme Disease/epidemiology , Borrelia burgdorferi/pathogenicity , Tick Infestations/complications , Enzyme-Linked Immunosorbent Assay , Cross-Sectional Studies , Antibodies/isolation & purificationSubject(s)
Humans , Skin Diseases, Vesiculobullous , Cardiolipins , Migraine Disorders , Neurologic ManifestationsABSTRACT
Se presenta la experiencia en 7 pacientes con antecedentes de pérdida recurrente del embarazo (x=3,7 rango 2-6) con AACL(+) en las cuales se descartó otra etiología; éstas pacientes totalizaban 26 gestaciones no tratadas concluidas en 24 pérdidas fetales (constando en 9 la muerte fetal in útero) y 2 RN vivos. La duración promedio de esas gestaciones fue 17,4 semanas (rango 8-37). Fueron tratadas con prednisona 20 mg/día y ASA 100 mg/día obteniéndose 7 RN vivos y 1 mortinato. En todas las pacientes se obtuvo descenso de los AACL. La duración promedio de las gestaciones tratadas fue de 31,7 semanas (rango 26-28). Se concluye que la presencia de AACL se correlaciona con alta mortalidad y bajo peso fetal y que con el tratamiento se obtiene gestaciones significativamente más largas que en las no tratadas y mayor relación de niños vivos respecto al número de embarazos