ABSTRACT
Objectives: Osteoporosis is a prevalent bone disease characterized by a decrease in bone mass and altered bone architecture leading to increased fracture risk. The present study aimed at evaluation of the impact of type 2 diabetes mellitus [T[2]DM] on bone mass and the status of bone turnover in postmenopausal females
Methodology: In this cross sectional study we evaluated bone turnover and bone mineral density [BMD] in 39 postmenopausal T[2]DM and 25 non-diabetic postmenopausal females. We measured serum levels of calcium, phosphate, osteocalcin, bone specific alkaline phosphatase [BS-ALP] and urinary excretion of c-terminal telopeptide cross links/creatinine ratio while BMD was evaluated by dual energy x-ray absorptiometry [DEXA]
Results: We found significantly higher BMD values for lumbar spine in the patients' group, [0.828 g/cm[2] for the study group and 0.720 g/cm[2] for controls]. Levels of, BS-ALP, osteocalcin and c-terminal telopeptide cross links/creatinine ratio were significantly lower in the diabetic subjects [68.667U/L, 3.856 ng/ml and 4.157 mg/mg creatinine respectively in the patient group versus 94.640 UL, 7.472 ng/ml and 5.851 mg/mg creatinine in the control group]
Conclusion: Our results suggested protective effect of T2DM on bone mass of lumbar spine together with decreased bone turnover in postmenopausal females